Perhaps the relative or absolute glucocorticoid deficiency after effective treatment of hypercortisolism alters immunologic responses and renders patients more vulnerable to thyrolytic processes.Įxacerbation and increased prevalence of autoimmune thyroid dysfunction after successful treatment of Cushing's syndrome have been described in small patient series in both ACTH-dependent and ACTH-independent clinical settings. The exact pathogenetic mechanism can only be speculated on. Conclusions: The incidence of DQT following the resolution of hypercortisolism, either medical or surgical, has not been previously described. Results: Oral glucocorticoid treatment was administered in both cases, resulting in prompt recovery. Both patients presented with clinical, functional, and imaging features of DQT at a time when their endogenous glucocorticoid levels were very low. The second patient had undergone unilateral adrenalectomy due to a cortisol-secreting adenoma and was on tapering doses of hydrocortisone due to a suppressed corticotroph axis. Her hypercortisolism was optimally controlled with a minimum dose. Methods: The first patient had been diagnosed with Cushing's disease due to a corticotroph pituitary microadenoma, declined neurosurgery, and was receiving pharmacological treatment with pasireotide. We describe 2 female patients with DQT coinciding with the resolution of hypercortisolism after treatment of Cushing's syndrome/disease. On the other hand, De Quervain's thyroiditis (DQT), in which autoimmunity is not a pathogenetic contributor, has not been reported during recovery from Cushing's syndrome. ![]() For Kinirons, whose writing credits include Kim Farrant’s 2015 Australian outback drama “Strangerland,” starring Nicole Kidman, Joseph Fiennes and Hugo Weaving, the unique and beautiful landscape partly inspired his idea for a very human.Objective: An increased prevalence of thyroid autoimmunity has been observed after successful treatment of Cushing's syndrome. Produced by Tiger Darling, the production shingle Kinirons runs with wife, producer Alicia Ní Ghráinne, the film is set in and around the picturesque West Cork fishing village of Baltimore, located near the southern tip of Ireland. “The Sparrow,” which screens out of competition at the Thessaloniki Film Festival, centers on Kevin ( Ollie West), a melancholic boy still grieving for his late mother and finding little consolation from his tough, emotionally distant father ( David O’Hara) or from his older brother ( Eanna Hardwicke). In his debut feature film, “The Sparrow,” writer-director Michael Kinirons explores the psychological struggle of a teenage boy dealing with unbearable guilt and the exacerbation of his quandary caused by his dysfunctional family situation. Ripley" (1999), Peter Jackson's " The Lord of the Rings" trilogy (2001–2003), " The Hobbit" trilogy (2012–2014), " Babel" (2006), " The Curious Case of Benjamin Button" (2008), " Indiana Jones and the Kingdom of the Crystal Skull" (2008), the " How to Train Your Dragon" film trilogy (2014–2019), " Cinderella" (2015), " Thor: Ragnarok" (2017) and " Ocean's 8" (2018). Blanchett's films include " The Talented Mr. Her other Oscar-nominated roles include " Notes on a Scandal" (2006), " Elizabeth: The Golden Age" (2007), " I'm Not There" (2007), and " Carol" (2015). She won a second Oscar for the comedy-drama " Blue Jasmine" (2013). ![]() Her portrayal of ' Katharine Hepburn' in Martin Scorsese's " The Aviator" (2004) earned her the 'Academy Award for Best Supporting Actress'. Actress Cate Blanchett, poses for the Armani floral fragrance 'Sì', photographed by Tom Munro: "The definition of iconic holiday elegance, Cate Blanchett captivates in the gold and red 'Armani' beauty holiday universe." Blanchett came to international attention portraying ' Elizabeth I' in the drama feature " Elizabeth" (1998).
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